Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
L-Alaninol → 6-[3-(4-Fluoro-phenyl)-isoxazol-4-ylmethoxy]-n-((s)-2-hydroxy-1-methyl-ethyl)-nicotinamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | L-Alaninol | HCID 80307 | — |
| 반응물 | 6-[3-(4-Fluoro-phenyl)-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester | HCID 68443977 | — |
| 생성물 | 6-[3-(4-Fluoro-phenyl)-isoxazol-4-ylmethoxy]-n-((s)-2-hydroxy-1-methyl-ethyl)-nicotinamide | HCID 42630544 | 59% |
반응 단계
As described for example 325, 6-[3-(4-fluoro-phenyl)-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester (60 mg, 0.18 mmol) was converted, using S-(+)-2-amino-1-propanol instead of rac-2-amino-1-propanol, to the title compound (28 mg, 59%) which was obtained as a white solid MS: m/e=370.3 [M−H]−.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08846719B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-86eee24f569d49758388980083c50d8d |
| 출처 메모 | uspto-grants-2014_09 |