Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanolamine → 6-[3-(4-Chloro-phenyl)-isoxazol-4-ylmethoxy]N-(2-hydroxy-ethyl)-nicotinamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanolamine | HCID 700 | — |
| 반응물 | 6-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid | HCID 66599213 | — |
| 반응물 | 6-[3-(4-Chloro-phenyl)-isoxazol-4-ylmethoxy]-nicotinic acid | HCID 68443769 | — |
| 생성물 | 6-[3-(4-Chloro-phenyl)-isoxazol-4-ylmethoxy]N-(2-hydroxy-ethyl)-nicotinamide | HCID 42630540 | 70% |
반응 단계
As described for example 191, 6-[3-(4-chloro-phenyl)-isoxazol-4-ylmethoxy]-nicotinic acid (100 mg, 0.3 mmol) was converted, instead of 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid, using ethanolamine instead of (1R,2R)-2-amino-cyclohexanol hydrochloride (1:1), to the title compound (79 mg, 70%) which was obtained as a white solid. MS: m/e=374.0 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08846719B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-4e42414a2d05401097a871f611f3898b |
| 출처 메모 | uspto-grants-2014_09 |