Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Amino-2-propanol → 6-[3-(4-Chloro-phenyl)-isoxazol-4-ylmethoxy]-n-(2-hydroxy-propyl)-nicotinamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Amino-2-propanol | HCID 4 | — |
| 반응물 | 6-[3-(4-Chloro-phenyl)-isoxazol-4-ylmethoxy]-nicotinic acid | HCID 68443769 | — |
| 생성물 | 6-[3-(4-Chloro-phenyl)-isoxazol-4-ylmethoxy]-n-(2-hydroxy-propyl)-nicotinamide | HCID 42630541 | 43% |
반응 단계
As described for example 346b, 6-[3-(4-chloro-phenyl)-isoxazol-4-ylmethoxy]-nicotinic acid (200 mg, 0.6 mmol) was converted, using (rac)-1-amino-2-propanol instead of ethanolamine, to the title compound (100 mg, 43%) which was obtained as a colourless gum. MS: m/e=388.1 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08846719B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-44fe2b6f6a484ae7b126349b18c1a432 |
| 출처 메모 | uspto-grants-2014_09 |