Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tert-butyl 3-aminoazetidine-1-carboxylate → 3-({6-[3-(4-Chloro-phenyl)-isoxazol-4-ylmethoxy]-pyridine-3-carbonyl}-amino)-azetidine-1-carboxylic acid tert-butyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tert-butyl 3-aminoazetidine-1-carboxylate | HCID 1516507 | — |
| 반응물 | 6-[3-(4-Chloro-phenyl)-isoxazol-4-ylmethoxy]-nicotinic acid | HCID 68443769 | — |
| 생성물 | 3-({6-[3-(4-Chloro-phenyl)-isoxazol-4-ylmethoxy]-pyridine-3-carbonyl}-amino)-azetidine-1-carboxylic acid tert-butyl ester | HCID 68442434 | 68% |
반응 단계
As described for example 346b, 6-[3-(4-chloro-phenyl)-isoxazol-4-ylmethoxy]-nicotinic acid (200 mg, 0.6 mmol) was converted, using 3-amino-1-N-Boc-azetidine instead of ethanolamine, to the title compound (200 mg, 68%) which was obtained as a colourless gum. MS: m/e=483.1 [M−H]−.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08846719B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-49219c4658b94abda1d419ae5771a36b |
| 출처 메모 | uspto-grants-2014_09 |