(2-(trifluoromethyl)phenyl)acetic acid → 5,7-Dichloro-1'-(2-(2-(trifluoromethyl)phenyl)acetyl)spiro[isoindoline-1,4'-piperidin]-3-one

반응식

[Cl:15][c:16]1[cH:17][c:18]2[c:22]([c:23]([Cl:25])[cH:24]1)[C:21]1([NH:20][C:19]2=[O:31])[CH2:26][CH2:27][NH:28][CH2:29][CH2:30]1.[F:1][C:2]([c:3]1[c:4]([CH2:9][C:10](=[O:11])[OH:12])[cH:5][cH:6][cH:7][cH:8]1)([F:13])[F:14]>>[F:1][C:2]([c:3]1[c:4]([CH2:9][C:10](=[O:12])[N:28]2[CH2:27][CH2:26][C:21]3([NH:20][C:19](=[O:31])[c:18]4[cH:17][c:16]([Cl:15])[cH:24][c:23]([Cl:25])[c:22]43)[CH2:30][CH2:29]2)[cH:5][cH:6][cH:7][cH:8]1)([F:13])[F:14]

참가 물질

반응물 2

HCID 594597(2-(trifluoromethyl)phenyl)acetic acid

HCID 582957645,7-Dichlorospiro[isoindoline-1,4'-piperidin]-3-one

생성물 1

HCID 582957375,7-Dichloro-1'-(2-(2-(trifluoromethyl)phenyl)acetyl)spiro[isoindoline-1,4'-piperidin]-3-one

출처 및 근거

ORD 기록: ord-68fd4557fba643e6adc731f052e3a0eb
출처 데이터셋: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

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