Anisole → 5-Oxopyrrolidine-3-carboxylic acid

HRID 83505노트

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HRID 83505 반응식
COC1C=C(OC)C=CC=1C[N:6]1[C:10](=[O:11])[CH2:9][CH:8]([C:12]([OH:14])=[O:13])[CH2:7]1.C1(OC)C=CC=CC=1>FC(F)(F)C(O)=O>[O:11]=[C:10]1[NH:6][CH2:7][CH:8]([C:12]([OH:14])=[O:13])[CH2:9]1

참가 물질

4

반응물 2

HCID 7519AnisoleHCID 112544611-(2,4-Dimethoxybenzyl)-5-oxopyrrolidine-3-carboxylic acid

생성물 1

HCID 167851365-Oxopyrrolidine-3-carboxylic acid수율 75%

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

반응 조건

온도
80 °C

실험 절차

To an optically active compound of 1-(2,4-dimethoxybenzyl)-5-oxopyrrolidine-3-carboxylic acid (14.3 g) were added anisole (8.4 ml) and trifluoroacetic acid (100 ml), and the mixture was stirred at 80° C. for 5 hours. This reaction solution was cooled to room temperature, and concentrated under reduced pressure. To the resulting residue was added diisopropyl ether (100 ml), and the mixture was stirred at room temperature. The insoluble substance was collected by filtration, washed with diisopropyl ether, and dried under reduced pressure to give the titled compound (4.96 g).

후처리

  1. temperatureThis reaction solution was cooled to room temperature
  2. concentrationconcentrated under reduced pressure
  3. additionTo the resulting residue was added diisopropyl ether (100 ml)
  4. stirringthe mixture was stirred at room temperature
  5. filtrationThe insoluble substance was collected by filtration
  6. washwashed with diisopropyl ether
  7. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-3902df9d1e3f4dd193d45df2dbdae501
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846746B2

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