HCID 86680359, 화합물 → (R)-3-Methyl-2-oxoimidazolidine-4-carboxylic Acid tert-butyl Ester

HRID 83518노트

반응식

HRID 83518 반응식
[C:1]([O:5][C:6]([C@H:8]1[CH2:12][N:11](C(OCC2C=CC=CC=2)=O)[C:10](=[O:23])[N:9]1[CH3:24])=[O:7])([CH3:4])([CH3:3])[CH3:2].[H][H]>CO.[Pd]>[C:1]([O:5][C:6]([C@H:8]1[CH2:12][NH:11][C:10](=[O:23])[N:9]1[CH3:24])=[O:7])([CH3:4])([CH3:3])[CH3:2]

참가 물질

5

반응물 2

HCID 86680359HCID 86680359, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 86680358(R)-3-Methyl-2-oxoimidazolidine-4-carboxylic Acid tert-butyl Ester수율 94%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of (R)-3-methyl-2-oxoimidazolidine-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester (167 mg) in methanol (1.7 ml) was added 10 wt % palladium on carbon at room temperature, and the mixture was stirred for 15 hours under one atom. of hydrogen. Under nitrogen atmosphere, this reaction solution was filtered through Celite, and eluted with methanol. The filtrate was concentrated under reduced pressure to give the titled compound (94 mg).

후처리

  1. filtrationUnder nitrogen atmosphere, this reaction solution was filtered through Celite
  2. washeluted with methanol
  3. concentrationThe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-0eb9d5403b344898ad5f9e392dd915fa
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846746B2

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