참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Hydrogen Bromide | HCID 260 | — |
| 반응물 | Dimethyl Sulfoxide | HCID 679 | — |
| 반응물 | p-Tolylthiourea | HCID 722833 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 2-Amino-6-methylbenzothiazole | HCID 17335 | 67% |
반응 단계
(4-Methylphenyl)thiourea (2 mmol) was added to AcOH (4 ml), and the suspension was heated to 80° C. To the solution formed was added 33% HBr in AcOH (4 mmol) followed by DMSO (2.1 mmol). After stirring at 80° C. for 1 h, the reaction mixture was cooled to 50° C., diluted with EtOAc (10 ml) and filtered. The product (as HBr-salt) was taken up in H2O (5 ml) and treated with 1M aq. NaHCO3 (2 ml). Stirring was continued for 0.2 h. The precipitated aminobenzothiazole was then filtered, washed with H2O (10 ml) and dried (16 h at 45° C./20 mb); yield 67%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07087761B2 |
|---|
| 출처 데이터셋 | uspto-grants-2006_08 |
|---|
| ORD ID | ord-2c38c04a2ff54f61871a1c6ab0095848 |
|---|
| 출처 메모 | uspto-grants-2006_08 |
|---|
