(4R)-3-[(Benzyloxy)carbonyl]-2-oxoimidazolidine-4-carboxylic acid → (4R)-2-oxoimidazolidine-4-carboxylic acid

HRID 83549노트

반응식

HRID 83549 반응식
C(OC([N:11]1[C@@H:15]([C:16]([OH:18])=[O:17])[CH2:14][NH:13][C:12]1=[O:19])=O)C1C=CC=CC=1.[H][H]>CO.O1CCCC1.[Pd]>[O:19]=[C:12]1[NH:11][C@@H:15]([C:16]([OH:18])=[O:17])[CH2:14][NH:13]1

참가 물질

5

반응물 2

HCID 688195(4R)-3-[(Benzyloxy)carbonyl]-2-oxoimidazolidine-4-carboxylic acidHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 7003745(4R)-2-oxoimidazolidine-4-carboxylic acid수율 71.3%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 21899815MeOH tetrahydrofuran용매

실험 절차

Under nitrogen atmosphere, to a solution of (R)-2-oxoimidazolidine-1,5-dicarboxylic acid 1-benzyl ester (1.61 g) in methanol/tetrahydrofuran (4/1, 20 ml) was added 10 wt % palladium on carbon (161 mg) at room temperature, and the mixture was stirred for 24 hours under one atmosphere of hydrogen. Under nitrogen atmosphere, palladium on carbon in this reaction solution was filtered off through Celite, and the filtrate was concentrated under reduced pressure. To the resulting residue were added diisopropyl ether and n-hexane, and the mixture was stirred. A solid was collected from this suspension by filtration, and dried under reduced pressure to give the titled compound (565 mg).

후처리

  1. filtrationUnder nitrogen atmosphere, palladium on carbon in this reaction solution was filtered off through Celite
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. additionTo the resulting residue were added diisopropyl ether and n-hexane
  4. filtrationA solid was collected from this suspension by filtration
  5. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-1a00e101946843eba1f536e4a40960ca
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846746B2

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