Bromine → 2-Bromo-1-[3-(3-chloro-propoxy)-phenyl]-ethanone

HRID 8358

반응식

HRID 8358 반응식
[Cl:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]([C:12](=[O:14])[CH3:13])[CH:9]=[CH:10][CH:11]=1.[Br:15]Br.C(=O)(O)[O-].[Na+]>CCOCC>[Br:15][CH2:13][C:12]([C:8]1[CH:9]=[CH:10][CH:11]=[C:6]([O:5][CH2:4][CH2:3][CH2:2][Cl:1])[CH:7]=1)=[O:14]

참가 물질

5

반응물 3

HCID 24408BromineHCID 516892Sodium BicarbonateHCID 143487521-[3-(3-Chloropropoxy)phenyl]ethanone

생성물 1

HCID 220155922-Bromo-1-[3-(3-chloro-propoxy)-phenyl]-ethanone

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A solution of the product of Step A (2.1 g) in ether (11 mL) was treated with bromine (0.53 mL) and the mixture stirred for 26 hours. The mixture was poured into saturated sodium bicarbonate solution (50 mL) and the organic layer was separated. The aqueous layer was washed with a fresh portion of ether (50 mL) and the combined organic layers were washed with brine (50 mL), dried over magnesium sulfate, filtered, and evaporated to yield the title compound (2.8 g).

후처리

  1. customthe organic layer was separated
  2. washThe aqueous layer was washed with a fresh portion of ether (50 mL)
  3. washthe combined organic layers were washed with brine (50 mL)
  4. dry with materialdried over magnesium sulfate
  5. filtrationfiltered
  6. customevaporated

출처 및 근거

ORD 기록
ord-dc9dcb2a36e24c068b009367510622ad
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087757B2

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