Bromine → 2-Bromo-1-[3-(3-chloro-propoxy)-phenyl]-ethanone
반응식
[Cl:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]([C:12](=[O:14])[CH3:13])[CH:9]=[CH:10][CH:11]=1.[Br:15]Br.C(=O)(O)[O-].[Na+]>CCOCC>[Br:15][CH2:13][C:12]([C:8]1[CH:9]=[CH:10][CH:11]=[C:6]([O:5][CH2:4][CH2:3][CH2:2][Cl:1])[CH:7]=1)=[O:14]참가 물질
5
실험 절차
A solution of the product of Step A (2.1 g) in ether (11 mL) was treated with bromine (0.53 mL) and the mixture stirred for 26 hours. The mixture was poured into saturated sodium bicarbonate solution (50 mL) and the organic layer was separated. The aqueous layer was washed with a fresh portion of ether (50 mL) and the combined organic layers were washed with brine (50 mL), dried over magnesium sulfate, filtered, and evaporated to yield the title compound (2.8 g).
후처리
- customthe organic layer was separated
- washThe aqueous layer was washed with a fresh portion of ether (50 mL)
- washthe combined organic layers were washed with brine (50 mL)
- dry with materialdried over magnesium sulfate
- filtrationfiltered
- customevaporated
출처 및 근거
- ORD 기록
- ord-dc9dcb2a36e24c068b009367510622ad
- 출처 데이터셋
- uspto-grants-2006_08
- 특허 번호
- US07087757B2
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