2,4-Dimethoxybenzylamine → HCID 71287769, 화합물

HRID 83583노트

반응식

HRID 83583 반응식
CO[C:3]([C:5]1([C:8]([C:10]([O:12][CH3:13])=[O:11])=[CH2:9])[CH2:7][CH2:6]1)=[O:4].[CH3:14][O:15][C:16]1[CH:23]=[C:22]([O:24][CH3:25])[CH:21]=[CH:20][C:17]=1[CH2:18][NH2:19]>C1(C)C=CC=CC=1>[CH3:13][O:12][C:10]([CH:8]1[C:5]2([CH2:6][CH2:7]2)[C:3](=[O:4])[N:19]([CH2:18][C:17]2[CH:20]=[CH:21][C:22]([O:24][CH3:25])=[CH:23][C:16]=2[O:15][CH3:14])[CH2:9]1)=[O:11]

참가 물질

4

반응물 2

HCID 5972502,4-DimethoxybenzylamineHCID 866803911-(1-Methoxycarbonylvinyl)cyclopropanecarboxylic Acid Methyl Ester

생성물 1

HCID 71287769HCID 71287769, 화합물

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a solution of 1-(1-methoxycarbonylvinyl)cyclopropanecarboxylic acid methyl ester (720 mg) in toluene (3.6 ml) was added 2,4-dimethoxybenzylamine (587 μl) at room temperature, and then the mixture was stirred at reflux for 20 hours. This reaction mixture was concentrated under reduced pressure, the resulting residue was purified by silica gel column chromatography (eluent: n-hexane/ethyl acetate=1/1) to give the titled compound (567 mg).

후처리

  1. temperatureat reflux for 20 hours
  2. concentrationThis reaction mixture was concentrated under reduced pressure
  3. customthe resulting residue was purified by silica gel column chromatography (eluent: n-hexane/ethyl acetate=1/1)

출처 및 근거

ORD 기록
ord-c90155ae579c439c8ebb8b7b6b0a8244
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846746B2

반응 노트

불러오는 중…