Trifluoroacetic acid → HCID 86680395, 화합물

HRID 83587노트

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HRID 83587 반응식
COC1C=C(OC)C=CC=1C[N:6]1[CH2:12][CH:11]([C:13]([OH:15])=[O:14])[C:8]2([CH2:10][CH2:9]2)[C:7]1=[O:16].C1(OC)C=CC=CC=1.FC(F)(F)C(O)=O>>[O:16]=[C:7]1[NH:6][CH2:12][CH:11]([C:13]([OH:15])=[O:14])[C:8]21[CH2:9][CH2:10]2

참가 물질

4

반응물 3

HCID 6422Trifluoroacetic acidHCID 7519AnisoleHCID 866803935-(2,4-Dimethoxybenzyl)-4-oxo-5-azaspiro[2.4]heptane-7-carboxylic Acid

생성물 1

HCID 86680395HCID 86680395, 화합물수율 76.2%

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온도
80 °C

실험 절차

To an optically active compound of 5-(2,4-dimethoxybenzyl)-4-oxo-5-azaspiro[2.4]heptane-7-carboxylic acid (372 mg) were sequentially added anisole (159 μl) and trifluoroacetic acid (5.6 ml) at room temperature, and the mixture was stirred at 80° C. for 4 hours. This reaction mixture was concentrated under reduced pressure, and diisopropyl ether (10 ml) was added thereto. The precipitated solid was collected by filtration to give the titled compound (144 mg).

후처리

  1. customat room temperature
  2. concentrationThis reaction mixture was concentrated under reduced pressure, and diisopropyl ether (10 ml)
  3. additionwas added
  4. filtrationThe precipitated solid was collected by filtration

출처 및 근거

ORD 기록
ord-a82509e990c64154b0a3ed9534001621
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846746B2

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