Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-[4-(3-Chloro-propoxy)-phenyl]-imidazo[1,2-a]pyridine → 2-[4-(3-Chloro-propoxy)-phenyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-[4-(3-Chloro-propoxy)-phenyl]-imidazo[1,2-a]pyridine | HCID 14097094 | — |
| 촉매 | Adams' catalyst | HCID 345198 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 2-[4-(3-Chloro-propoxy)-phenyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine | HCID 22015627 | 96.4% |
반응 단계
To a Parr bottle charged with a mixture of platinum (IV) oxide (30 mg) in ethanol (3 mL) was added a solution of the product of Step A (90 mg) in methanol (6 ml). The mixture was hydrogenated at 40 psi for 4 hours and filtered through a Celite pad which was rinsed with several additional milliliters of methanol and ethanol. The filtrate was collected and evaporated in vacuo to yield the title compound (88 mg) which was used without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07087757B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-838c0cefe9b94edaae563cc0b0c31601 |
| 출처 메모 | uspto-grants-2006_08 |