Boron tribromide → 3-Chloro-4,5-dihydroxybenzaldehyde
반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([O:11]C)[C:9]=1[OH:10])[CH:5]=[O:6].B(Br)(Br)Br>ClCCl>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([OH:11])[C:9]=1[OH:10])[CH:5]=[O:6]참가 물질
4
실험 절차
To a suspension of 3-chloro-4-hydroxy-5-methoxy-benzaldehyde (10 g, 54 mmol) in dichloromethane (300 mL) was added BBr3 (26.7 g, 107 mmol) dropwise at −40° C. under N2. After addition, the mixture was stirred at this temperature for 5 h and then was poured into ice water. The precipitated solid was filtered and washed with petroleum ether. The filtrate was evaporated under reduced pressure to afford 3-chloro-4,5-dihydroxybenzaldehyde (9.8 g, 89%), which was directly used in the next step.
후처리
- additionAfter addition
- filtrationThe precipitated solid was filtered
- washwashed with petroleum ether
- customThe filtrate was evaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-84f89e65065d4550a32da904da12c408
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08846753B2
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