Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Amino-4-methylpyridine → 2-(4'-Chloropropoxy-3'-methoxyphenyl)-7-methylimidazo[1,2-a]pyridine hydrobromide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Amino-4-methylpyridine | HCID 1533 | — |
| 반응물 | alpha-Bromo-3'-methoxy-4'-chloropropoxyacetophenone | HCID 22015629 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 2-(4'-Chloropropoxy-3'-methoxyphenyl)-7-methylimidazo[1,2-a]pyridine hydrobromide | HCID 22015598 | 70.5% |
반응 단계
A solution of the product of Step B (1.44 g) and 2-amino-4-picoline (0.486 g) in ethanol (6 mL) was heated at 73° C. for 1 hour. The reaction mixture was cooled to ambient temperature and evaporated to a yellow solid. The solid was stirred with 25 mL of dichloromethane for approximately 10 minutes. The mixture was filtered and the solid product collected to yield the title compound (1.3 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07087757B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-979a976b36f74db790007f7dd4f936ca |
| 출처 메모 | uspto-grants-2006_08 |