Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → 3-Bromo-4-methoxyaniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Stannous chloride dihydrate | HCID 61436 | — |
| 반응물 | 2-Bromo-4-nitroanisole | HCID 78870 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 3-Bromo-4-methoxyaniline | HCID 961083 | 92.6% |
반응 단계
2-Bromo-1-methoxy-4-nitrobenzene (2.50 g, 10.8 mmol), SnCl2.2H2O (12.2 g, 53.9 mmol), and MeOH (30 mL) were combined and allowed to stir for 3 h at ambient temperature. To the mixture was added H2O (100 mL) and EtOAc (100 mL) resulting in the formation of a thick emulsion. To this was added sat. aq. NaHCO3 (30 mL). The layers were separated and the aqueous layer was extracted with EtOAc (3×30 mL). The organics were combined and dried over MgSO4 before being filtered. Concentration of the filtrate in vacuo gave 2.02 g of an off-white solid. This material was used without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08846753B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-a48eb89408e442eaa73e43e78766a091 |
| 출처 메모 | uspto-grants-2014_09 |