Dichloromethane → 1-(Benzo[d][1,3]dioxol-5-yl)cyclopropanecarbonyl chloride

참여 물질

역할	이름	HCID	투입량
반응물	Dichloromethane	HCID 6344	—
반응물	Thionyl Chloride	HCID 24386	—
반응물	1-(1,3-Dioxaindan-5-yl)cyclopropane-1-carboxylic acid	HCID 14349608	—
용매	Dimethylformamide	HCID 6228	—
생성물	1-(Benzo[d][1,3]dioxol-5-yl)cyclopropanecarbonyl chloride	HCID 59129154	—

반응 단계

To an oven-dried round bottom flask containing 1-(benzo[d][1,3]dioxol-5-yl)-cyclopropanecarboxylic acid (A-8) (618 mg, 3.0 mmol) and CH2Cl2 (3 mL) was added thionyl chloride (1.07 g, 9.0 mmol) and N,N-dimethylformamide (0.1 mL). The reaction mixture was stirred at ambient temperature under an Ar atmosphere until the gas evolution ceased (2-3 h). The excess thionyl chloride was removed under vacuum and the resulting residue dissolved in CH2Cl2 (3 mL). The mixture was used without further manipulation.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08846753B2
출처 데이터셋	uspto-grants-2014_09
ORD ID	ord-b9a424f48cb942e69d8f2d0e689c65ef
출처 메모	uspto-grants-2014_09