Piperazine → Pyrimido(5,4-d)pyrimidin-4-amine, N-methyl-N-(phenylmethyl)-6-(1-piperazinyl)-8-(4-thiomorpholinyl)-, S-oxide

반응식

[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]([c:9]1[n:10][cH:11][n:12][c:13]2[c:14]1[n:15][c:16]([Cl:26])[n:17][c:18]2[N:19]1[CH2:20][CH2:21][S:22](=[O:25])[CH2:23][CH2:24]1)[CH3:27].[CH2:28]1[CH2:29][NH:30][CH2:31][CH2:32][NH:33]1.[O:34]1[CH2:35][CH2:36][O:37][CH2:38][CH2:39]1>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]([c:9]1[n:10][cH:11][n:12][c:13]2[c:14]1[n:15][c:16]([N:30]1[CH2:29][CH2:28][NH:33][CH2:32][CH2:31]1)[n:17][c:18]2[N:19]1[CH2:20][CH2:21][S:22](=[O:25])[CH2:23][CH2:24]1)[CH3:27]

참가 물질

반응물 3

HCID 4837Piperazine

HCID 312751,4-Dioxane

HCID 128169948-(N-Benzyl-methylamino)-2-chloro-4-(1-oxido-thiomorpholino)pyrimido[5,4-d]pyrimidine

생성물 1

HCID 3061030Pyrimido(5,4-d)pyrimidin-4-amine, N-methyl-N-(phenylmethyl)-6-(1-piperazinyl)-8-(4-thiomorpholinyl)-, S-oxide

출처 및 근거

ORD 기록: ord-f7dc0138cdcc4707a60c71086f9cb82b
출처 데이터셋: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

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