Piperidine → 4-Piperidinylbut-1-ene

반응식

Br[CH2:2][CH2:3][CH:4]=[CH2:5].[NH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1>>[N:6]1([CH2:7][CH2:8][CH:9]=[CH2:10])[CH2:11][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

반응물 2

HCID 8082Piperidine

HCID 21241Homoallyl bromide

생성물 1

HCID 45622824-Piperidinylbut-1-ene수율 93.4%

실험 절차

4-Bromobut-1-ene (1.35 g) was treated with piperidine (1.7 g) and heated at reflux for 3 hours. The mixture was cooled to ambient temperature, filtered and the residue washed with ether (50 mL). The combined filtrate and washings were evaporated to give the title compound (1.3 g).

후처리

temperatureheated
temperatureat reflux for 3 hours
filtrationfiltered
washthe residue washed with ether (50 mL)
customThe combined filtrate and washings were evaporated

출처 및 근거

ORD 기록: ord-d7ef957ab1cf46f68f1f4c42cdc7ceea
출처 데이터셋: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07087757B2

반응 노트

불러오는 중…