Piperidine → 4-Piperidinylbut-1-ene

반응식

Br[CH2:2][CH2:3][CH:4]=[CH2:5].[NH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1>>[N:6]1([CH2:7][CH2:8][CH:9]=[CH2:10])[CH2:11][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

반응물 2

HCID 8082Piperidine

HCID 21241Homoallyl bromide

생성물 1

HCID 45622824-Piperidinylbut-1-ene수율 93.4%

실험 절차

A mixture of 1-bromo-3-butene (1.35 g, 10 mmol) and piperidine (1.70 g, 20 mmol) neat was refluxed under nitrogen atmosphere for 3 h. Cooled to RT, filtered and dissolved into ethyl ether (40 mL). Then solution was washed with water (2×30 mL) and dried over anhydrous Na2SO4, filtered and evaporated to dryness to yield 1.3 g (74.15%) oily 1-piperidyl-3-butene.

후처리

temperatureneat was refluxed under nitrogen atmosphere for 3 h
filtrationfiltered
dissolutiondissolved into ethyl ether (40 mL)
washThen solution was washed with water (2×30 mL)
dry with materialdried over anhydrous Na2SO4
filtrationfiltered
customevaporated to dryness

출처 및 근거

ORD 기록: ord-2927bd8c3c9846bbb36c39855a81a50c
출처 데이터셋: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07087757B2

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