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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 8385생성일: 2026년 10월 24일

Epichlorohydrin → 2-[4-[(2,3-Epoxy)propoxy]phenyl]-8-methylimidazo[1,2-a]pyridine

https://huagongshe.com/ko/reaction/8385

반응식

참여 물질

역할이름HCID투입량
반응물EpichlorohydrinHCID 7835—
반응물Potassium HydroxideHCID 14797—
반응물2-[4-Hydroxyphenyl]-8-methylimidazo[1,2-a]pyridineHCID 22015659—
용매MethanolHCID 887—
용매DichloromethaneHCID 6344—
생성물2-[4-[(2,3-Epoxy)propoxy]phenyl]-8-methylimidazo[1,2-a]pyridineHCID 22015632—

반응 단계

The product of Step B (27 g) in methanol (500 mL) was treated with potassium hydroxide (14 g) and stirred at ambient temperature for 2 hours. To this solution was then added epichlorohydrin (9.4 mL) and the mixture stirred for an additional 48 hours. The reaction mixture was diluted with dichloromethane, filtered and the filtrate washed with water, dried, sodium sulfate filtered and evaporated to afford the title compound (18.2 g).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07087757B2
출처 데이터셋uspto-grants-2006_08
ORD IDord-adab4b87712c4dafbdcd55a8abd05d2f
출처 메모uspto-grants-2006_08