Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Epichlorohydrin → 2-[4-[(2,3-Epoxy)propoxy]phenyl]-8-methylimidazo[1,2-a]pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Epichlorohydrin | HCID 7835 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | 2-[4-Hydroxyphenyl]-8-methylimidazo[1,2-a]pyridine | HCID 22015659 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-[4-[(2,3-Epoxy)propoxy]phenyl]-8-methylimidazo[1,2-a]pyridine | HCID 22015632 | — |
반응 단계
The product of Step B (27 g) in methanol (500 mL) was treated with potassium hydroxide (14 g) and stirred at ambient temperature for 2 hours. To this solution was then added epichlorohydrin (9.4 mL) and the mixture stirred for an additional 48 hours. The reaction mixture was diluted with dichloromethane, filtered and the filtrate washed with water, dried, sodium sulfate filtered and evaporated to afford the title compound (18.2 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07087757B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-adab4b87712c4dafbdcd55a8abd05d2f |
| 출처 메모 | uspto-grants-2006_08 |