Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Epichlorohydrin → 7-(2,3-Epoxypropoxy)-2,2-dimethyl-4-phenylchroman
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Epichlorohydrin | HCID 7835 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2,2-Dimethyl-7-hydroxy-4-phenylchroman | HCID 20570531 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | 7-(2,3-Epoxypropoxy)-2,2-dimethyl-4-phenylchroman | HCID 23330756 | 95% |
반응 단계
A mixture of 7-hydroxy-2,2-dimethyl-4-phenylchroman (11.8g, .046 mole), anhydrous potassium carbonate (11.7g, 0.093 mole), epichlorohydrin (50ml) and dry acetone (50ml) was stirred and boiled under reflux for 6 hours, then cooled and filtered. The filtrate was evaporated in vacuo and the residual brown oil dissolved in ether, washed with water and dried (magnesium sulphate). Removal of the solvent gave 7-(2,3-epoxypropoxy)-2,2-dimethyl-4-phenylchroman as a pale brown solid (13.56g, 95%), m.p. 82°-85°, after crystallization from ethanol.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04093631 |
| 출처 데이터셋 | uspto-grants-1978_06 |
| ORD ID | ord-635f87242d28449a9321f53824cbd9d3 |
| 출처 메모 | uspto-grants-1978_06 |