Methylamine → 4-(1-Naphthyl)-2,2-dimethyl-7-(3-methylamino-2-hydroxy-propoxy)-2H chromene

참여 물질

역할	이름	HCID	투입량
반응물	Methylamine	HCID 6329	—
반응물	2,2-Dimethyl-4-(naphthalen-1-yl)-7-[(oxiran-2-yl)methoxy]-2H-1-benzopyran	HCID 23330742	—
용매	Ethanol	HCID 702	—
생성물	4-(1-Naphthyl)-2,2-dimethyl-7-(3-methylamino-2-hydroxy-propoxy)-2H chromene	HCID 54425743	63%

반응 단계

Methylamine (9.5 ml) was added to 7-(2,3-epoxypropoxy)-2,2-dimethyl-4-(1-naphthyl)-2H chromene (4.5g., 0.013 moles) in ethanol (9.5ml) and the solution left to stand at room temperature for 48 hours. Removal of solvent gave the title compound as an orange oil (3.2g., 63%). N.M.R. (τCDCl3) 8.54(s, 3H, CH3 --), 8.48(s, 3H, CH3 --), 7.06(s, 3H, N--CH3), 6.72(d, 2H, --CHCH2 --), 6.05(d, 2H, --CH2CH--), 4.51(s, 1H, vinylic CH), 3.40-3.80 (m, 3H, aromatic H's), 2.10-2.75(m, 7H, aromatic H's).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US04093631
출처 데이터셋	uspto-grants-1978_06
ORD ID	ord-85338c0b14c445b9b7ea6e29d9ce55bd
출처 메모	uspto-grants-1978_06