Acetic Acid → HCID 12468024, 화합물

HRID 838987노트

반응식

HRID 838987 반응식
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7]1=[N:11][C:12]([CH3:14])=[N:13][N:6]1[C:5]2([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)N.C(O)(=[O:24])C>CO>[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([C:7]2[N:11]=[C:12]([CH3:14])[NH:13][N:6]=2)=[C:4]([CH:3]=1)[C:5]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:24]

참가 물질

4

반응물 2

HCID 176Acetic AcidHCID 124680237-Chloro-2-methyl-5-phenyl-5H-[1,2,4]triazolo[5,1-a]isoindol-5-amine

생성물 1

HCID 12468024HCID 12468024, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Ten milligrams of 7-chloro-2-methyl-5-phenyl-5H-[1,2,4]triazolo-[5,1-a]-isoindol-5-amine (as prepared in Example 1) are refluxed for 10 minutes in 2 ml of 50% aqueous methanol containing a drop of acetic acid. The methanol is removed under vacuum and the aqueous residue made basic with 10% NaOH. The aqueous solution is washed with chloroform, neutralized with 10% HCl and extracted with chloroform. The chloroform solution is evaporated to dryness and the residue is recrystallized from a water-ethanol mixture, m.p. 148° to 150°.

후처리

  1. customThe methanol is removed under vacuum
  2. washThe aqueous solution is washed with chloroform
  3. extractionextracted with chloroform
  4. customThe chloroform solution is evaporated to dryness
  5. customthe residue is recrystallized from a water-ethanol mixture, m.p. 148° to 150°

출처 및 근거

ORD 기록
ord-95521dd341d04b28832e432b26c2ef8d
출처 데이터셋
uspto-grants-1978_06
특허 번호
US04093728

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