Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Butanedione → 4,5-Dimethyl-2-phenylimidazoline-4,5-diol Hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Butanedione | HCID 650 | — |
| 반응물 | Isopropanol | HCID 3776 | — |
| 반응물 | Benzamidine HCl hydrate | HCID 16219042 | — |
| 반응물 | Acetic acid, sodium salt, monohydrate | HCID 23681166 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4,5-Dimethyl-2-phenylimidazoline-4,5-diol Hydrochloride | HCID 20325898 | — |
반응 단계
To 56.4 g (0.323 mole) of benzamidine hydrochloride hydrate in 200 ml of warm water is added with vigorous stirring 40 ml of biacetyl. Within a few minutes a heavy precipitate forms and 150 ml of isopropyl alcohol is added followed by 5.0 g of sodium acetate hydrate dissolved in 15 ml of warm water. Stirring is continued for 4 hours after which time the product, 4,5-dimethyl-2-phenylimidazoline-4,5-diol hydrochloride, is filtered off and washed with isopropyl alcohol. Recrystallization from 95% ethanol gives the pure product, m.p. 162°-165° C (dec.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04093811 |
| 출처 데이터셋 | uspto-grants-1978_06 |
| ORD ID | ord-8f7774b36d9c43039c71186ef27c33d7 |
| 출처 메모 | uspto-grants-1978_06 |