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Potassium Iodide → 4-{6-[4-(2-Ethoxyethoxy)phenyl]hexyl}-3,5-heptanedione

HRID 839176
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HRID 839176 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH:14]([C:19](=[O:22])[CH2:20][CH3:21])[C:15](=[O:18])[CH2:16][CH3:17])=[CH:4][CH:3]=1.[CH2:23]([O:25][CH2:26][CH2:27]Br)[CH3:24].C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>CC(C)=O>[CH2:23]([O:25][CH2:26][CH2:27][O:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH:14]([C:15](=[O:18])[CH2:16][CH3:17])[C:19](=[O:22])[CH2:20][CH3:21])=[CH:6][CH:7]=1)[CH3:24]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 611412-Bromoethyl ethyl etherHCID 5143233,5-Heptanedione, 4-[6-(4-hydroxyphenyl)hexyl]-

생성물 1

HCID 234557264-{6-[4-(2-Ethoxyethoxy)phenyl]hexyl}-3,5-heptanedione

시약·촉매·용매 1

HCID 180Acetone
용매

실험 절차

A mixture of 3.9 g. of 4-[6-(4-hydroxyphenyl)hexyl]-3,5-heptanedione (Example 28), 12 g. of 2-bromoethyl ethyl ether, 4 g. of potassium carbonate and 1 g. of potassium iodide in 40 ml. of acetone was heated at reflux for 48 hours and then allowed to stand at room temperature for three days. The reaction mixture was then filtered and concentrated to remove the solvent. The residue was distilled at 200°-205° C. (0.001 mm.) to give 4-{6-[4-(2-ethoxyethoxy)phenyl]hexyl}-3,5-heptanedione as a light yellow oil.

후처리

  1. additionA mixture of 3.9 g
  2. temperatureat reflux for 48 hours
  3. filtrationThe reaction mixture was then filtered
  4. concentrationconcentrated
  5. customto remove the solvent
  6. distillationThe residue was distilled at 200°-205° C. (0.001 mm.)

출처 및 근거

ORD 기록
ord-d3680836ed314e42b2181c3137bf2c32
출처 데이터셋
uspto-grants-1978_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04093736

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