Isopropylamine → HCID 12801064, 화합물

HRID 839390노트

반응식

HRID 839390 반응식
[Cl:1][C:2]1[CH:22]=[CH:21][C:5]([O:6][CH2:7][CH:8]2[CH2:13][N:12]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH2:11][C:10](=[O:20])[O:9]2)=[CH:4][CH:3]=1.[CH:23]([NH2:26])([CH3:25])[CH3:24]>O1CCOCC1>[Cl:1][C:2]1[CH:22]=[CH:21][C:5]([O:6][CH2:7][CH:8]([OH:9])[CH2:13][N:12]([CH2:11][C:10]([NH:26][CH:23]([CH3:25])[CH3:24])=[O:20])[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 6363IsopropylamineHCID 203059606-[(4-Chlorophenoxy)methyl]-4-phenylmorpholin-2-one

생성물 1

HCID 12801064HCID 12801064, 화합물수율 10.5%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

After 7.0 g (0.22 moles) of 6-(p-chlorophenoxymethyl)-4-phenyl-2-morpholinone and 20 g of isopropylamine were dissolved in 50 ml of dioxane and the resulting Solution was left to stand overnight at room temperature, the reaction mixture was concentrated in vacuo. The residue was solidified by addition of a small amount of ether. The solid was filtered, washed with ether and dried to give 8.7 g of the product. Recrystallization from ethanol afforded 5.5 g (66.3%) of crystals, with a melting point of 140.5° to 142.5°.

후처리

  1. waitthe resulting Solution was left
  2. concentrationthe reaction mixture was concentrated in vacuo
  3. additionThe residue was solidified by addition of a small amount of ether
  4. filtrationThe solid was filtered
  5. washwashed with ether
  6. customdried

출처 및 근거

ORD 기록
ord-05e461e1ec004d70bdeaae4b91b7ee36
출처 데이터셋
uspto-grants-1978_06
특허 번호
US04094991

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