참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Chloromethyl Methyl Ether | HCID 7864 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | p-Hydroxyphenylglycine methyl ester | HCID 4123006 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Methyl alpha-amino-alpha-(4-methoxymethoxyphenyl)acetate | HCID 20324417 | — |
반응 단계
In this preparation 1.81 g. of methyl α-amino-α-(4-hydroxyphenyl)acetate is dissolved in 10 ml. of dimethylformamide under nitrogen and 0.24 g. of sodium hydride is then added. The solution is stirred at room temperature under nitrogen until hydrogen evolution ceases and then 0.80 g. of chloromethyl methyl ether is added. The resulting mixture is warmed at 60° C for 1 hour and then cooled and diluted with water. The aqueous mixture is extracted with ether and the ether extract is dried and evaporated to afford methyl α-amino-α-(4-methoxymethoxyphenyl)acetate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04094978 |
|---|
| 출처 데이터셋 | uspto-grants-1978_06 |
|---|
| ORD ID | ord-b59e5b18ad26420caf07f211fcad7334 |
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| 출처 메모 | uspto-grants-1978_06 |
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