Chlorodiethylphosphine → Diethyl(4-methoxyphenyl)phosphine

HRID 839576

반응식

HRID 839576 반응식
[CH2:1]([P:3](Cl)[CH2:4][CH3:5])[CH3:2].[CH3:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([Li])=[CH:11][CH:10]=1.IC1C=CC(OC)=CC=1>CCOCC>[CH2:1]([P:3]([CH2:4][CH3:5])[C:12]1[CH:13]=[CH:14][C:9]([O:8][CH3:7])=[CH:10][CH:11]=1)[CH3:2]

참가 물질

5

반응물 3

HCID 69639ChlorodiethylphosphineHCID 696764-IodoanisoleHCID 178506735HCID 178506735, 화합물

생성물 1

HCID 20323552Diethyl(4-methoxyphenyl)phosphine

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A solution of 10 g. (0.08 mole) of diethylphosphinous chloride in 100 ml. of ether was added to a solution of p-methoxyphenyllithium [prepared from 23.4 g. (0.1 mole) of p-iodoanisole in 100 ml. of ether and 62.5 ml. of 1.6 M n-butyllithium in hexane] under a nitrogen atmosphere. After 40 minutes, the reaction mixture was filtered and the solvent removed at reduced pressure. Distillation of the residual oil gave (diethyl)(p-methoxyphenyl)phosphine as a colorless liquid, b.p. 85°-90° C. at 0.5 mm.

후처리

  1. filtrationthe reaction mixture was filtered
  2. customthe solvent removed at reduced pressure
  3. distillationDistillation of the residual oil

출처 및 근거

ORD 기록
ord-3f82d9807b7849d1a9c41cf9b6979506
출처 데이터셋
uspto-grants-1978_06
특허 번호
US04096250

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