Chlorosulfonic acid → 2-(Methoxycarbonylamino) 6-(p-chlorosulfonylphenylthio) imidazo [1,2-a] pyridine

HRID 839628노트

반응식

HRID 839628 반응식
[CH3:1][O:2][C:3]([NH:5][C:6]1[N:7]=[C:8]2[CH:13]=[CH:12][C:11]([S:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[CH:10][N:9]2[CH:21]=1)=[O:4].[Cl:22][S:23](O)(=[O:25])=[O:24]>>[CH3:1][O:2][C:3]([NH:5][C:6]1[N:7]=[C:8]2[CH:13]=[CH:12][C:11]([S:14][C:15]3[CH:16]=[CH:17][C:18]([S:23]([Cl:22])(=[O:25])=[O:24])=[CH:19][CH:20]=3)=[CH:10][N:9]2[CH:21]=1)=[O:4]

참가 물질

3

반응물 2

HCID 24638Chlorosulfonic acidHCID 12414300Methyl [6-(phenylsulfanyl)imidazo[1,2-a]pyridin-2-yl]carbamate

생성물 1

HCID 537731502-(Methoxycarbonylamino) 6-(p-chlorosulfonylphenylthio) imidazo [1,2-a] pyridine

실험 절차

4.5 gms. (0.015 mole) of 2-methoxycarbonylamino 6-(phenylthio) imidazo [1,2-a] pyridine is added portionwise to 45 ml. of chlorosulfonic acid at 0° to -5° C. The reaction mixture is stirred at room temperature for 24 hours. The solution is poured onto ice and the solids are collected by filtration. After repeated washes with water, the crude chlorosulfonic acid derivative is dried at room temperature in vacuo.

후처리

  1. customat 0° to -5° C
  2. additionThe solution is poured onto ice
  3. filtrationthe solids are collected by filtration
  4. dry with materialthe crude chlorosulfonic acid derivative is dried at room temperature in vacuo

출처 및 근거

ORD 기록
ord-6c8dbdfa11fb4c17956239422d7c5570
출처 데이터셋
uspto-grants-1978_06
특허 번호
US04096264

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