2-Pyridinamine, 5-iodo- → 5-phenoxypyridin-2-amine

HRID 839635

반응식

HRID 839635 반응식
[C:1]1([O-:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[K+].[NH2:9][C:10]1[CH:15]=[CH:14][C:13](I)=[CH:12][N:11]=1>CC(N(C)C)=O>[NH2:9][C:10]1[CH:15]=[CH:14][C:13]([O:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[CH:12][N:11]=1

참가 물질

4

반응물 2

HCID 885792-Pyridinamine, 5-iodo-HCID 23670670Potassium phenoxide

생성물 1

HCID 221794545-phenoxypyridin-2-amine

시약·촉매·용매 1

HCID 31374Dimethylacetamide용매

실험 절차

3.3 G. of potassium phenolate, 5.47 g. of 2-amino 5-iodopyridine and 1.78 g. of cuprous oxide in 150 ml. of dimethylacetamide are heated at reflux under a nitrogen atmosphere for 24 hours. The solvent is removed in vacuo and the residue is extracted with chloroform. Chromatography of the methylene chloride soluble portion with silica gel and elution with ethyl acetate yields 2-amino-5-phenoxy pyridine m.p. 67°-69° C.

후처리

  1. temperatureat reflux under a nitrogen atmosphere for 24 hours
  2. customThe solvent is removed in vacuo
  3. extractionthe residue is extracted with chloroform
  4. washChromatography of the methylene chloride soluble portion with silica gel and elution with ethyl acetate

출처 및 근거

ORD 기록
ord-eaa44ef71d95469786d79e2ca79f7d0d
출처 데이터셋
uspto-grants-1978_06
특허 번호
US04096264

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