Hydroquinone → 4-(3-Bromopropoxy)phenol
반응식
[C:1]1([CH:8]=[CH:7][C:5]([OH:6])=[CH:4][CH:3]=1)[OH:2].[Br:9][CH2:10][CH2:11][CH2:12]Br.C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[Br:9][CH2:10][CH2:11][CH2:12][O:2][C:1]1[CH:8]=[CH:7][C:5]([OH:6])=[CH:4][CH:3]=1참가 물질
5
실험 절차
A mixture of 88.0 g. (0.80 m.) of hydroquinone, 161.6 g. (0.80 m.) of 1,3-dibromopropane and 55.2 g. (0.40 m.) of potassium carbonate in 2 liters of 2-butanone was heated at reflux for 24 hours. The reaction mixture was filtered and the filtrate concentrated in vacuo. The solid and liquid phases of the residue were separated, and the liquid fraction was chromatographed on silica gel using chloroform-acetonitrile (95:5) as the eluant. There was thus obtained 37.2 g. of 4-(3-bromopropyloxy)phenol as a light brown oil which was used directly in the next reaction.
후처리
- additionA mixture of 88.0 g
- temperatureat reflux for 24 hours
- filtrationThe reaction mixture was filtered
- concentrationthe filtrate concentrated in vacuo
- customThe solid and liquid phases of the residue were separated
- customthe liquid fraction was chromatographed on silica gel
- customof 4-(3-bromopropyloxy)phenol as a light brown oil which was used directly in the next reaction
출처 및 근거
- ORD 기록
- ord-23bd87595a53454f8e2b7128ace45f69
- 출처 데이터셋
- uspto-grants-1978_06
- 특허 번호
- US04096280
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