Water → N-(7-Oxo-4,5,6,7-tetrahydro-1-benzothiophen-4-yl)formamide

HRID 839745노트

반응식

HRID 839745 반응식
S1CCS[C:2]21[C:10]1[S:11][CH:12]=[CH:13][C:9]=1[CH:8]([NH:14][CH:15]=[O:16])[CH2:7][CH2:6]2.O.C(=O)([O-])[O-:19].[Ca+2]>C(#N)C>[O:19]=[C:2]1[C:10]2[S:11][CH:12]=[CH:13][C:9]=2[CH:8]([NH:14][CH:15]=[O:16])[CH2:7][CH2:6]1

참가 물질

5

반응물 3

HCID 962WaterHCID 10112Calcium CarbonateHCID 86735494N-(5,6-dihydrospiro[benzo-[b]thiophen-7(4H), 2'-[1,3]dithiolan]-4-yl)formamide

생성물 1

HCID 23347790N-(7-Oxo-4,5,6,7-tetrahydro-1-benzothiophen-4-yl)formamide

시약·촉매·용매 1

HCID 6342Acetonitrile용매2회

실험 절차

To a stirred mixture of N-(5,6-dihydrospiro[benzo-[b]thiophen-7(4H), 2'-[1,3]dithiolan]-4-yl)formamide (1.5 g), acetonitrile (20 ml) and water is added calcium carbonate (1.65 g) and mercuric chloride (3.0 g). The mixture is stirred at room temperature for 35 minutes and acetonitrile is added. The solid is filtered and washed with acetonitrile. The filtrate (100 ml) is evaporated to dryness to afford the title compound.

후처리

  1. filtrationThe solid is filtered
  2. washwashed with acetonitrile
  3. customThe filtrate (100 ml) is evaporated to dryness

출처 및 근거

ORD 기록
ord-713ce4782ce747b09cbf1e4a9bc7fe22
출처 데이터셋
uspto-grants-1978_06
특허 번호
US04096155

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