Urea → 1-(2-Ethylhexanoyl)urea

HRID 83976

반응식

HRID 83976 반응식
[CH2:1]([CH:3]([CH2:7][CH2:8][CH2:9][CH3:10])[C:4](Cl)=[O:5])[CH3:2].[NH2:11][C:12]([NH2:14])=[O:13]>C(#N)C>[CH2:1]([CH:3]([CH2:7][CH2:8][CH2:9][CH3:10])[C:4]([NH:11][C:12]([NH2:14])=[O:13])=[O:5])[CH3:2]

참가 물질

4

반응물 2

HCID 1176UreaHCID 791032-Ethylhexanoyl chloride

생성물 1

HCID 2252551-(2-Ethylhexanoyl)urea

시약·촉매·용매 1

HCID 6342Acetonitrile용매2회

실험 절차

2-Ethyl-hexanoylchloride (0.057 mol, Sigma-Aldrich Israel Ltd.), dissolved in dry acetonitrile (50 ml), was slowly added to a dry, boiling solution of urea (0.14 mole) in acetonitrile (100 ml) and allowed to reflux for 2 hours. Thereafter the organic solvent was evaporated under reduced pressure and the product was dissolved in ethyl acetate (100 ml) and washed three times with 20 ml of distilled water. The organic fraction was dried over MgSO4, filtered and evaporated under reduced pressure. The product was purified by crystallization from ethyl acetate.

후처리

  1. additionwas slowly added to a dry
  2. temperatureto reflux for 2 hours
  3. customThereafter the organic solvent was evaporated under reduced pressure
  4. dissolutionthe product was dissolved in ethyl acetate (100 ml)
  5. washwashed three times with 20 ml of distilled water
  6. dry with materialThe organic fraction was dried over MgSO4
  7. filtrationfiltered
  8. customevaporated under reduced pressure
  9. customThe product was purified by crystallization from ethyl acetate

출처 및 근거

ORD 기록
ord-39f9ec2458c94c82a5b93820c547afd0
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846903B2

연결된 노트

불러오는 중…