Phosgene → HCID 54006150, 화합물

HRID 839953노트

반응식

HRID 839953 반응식
Cl.[C:2]1([CH:8]([O:15][C:16](=[O:19])[CH2:17][NH2:18])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(C1C=CC(C)=CC=1)(O)(=O)=O.NC[C:33](O)=[O:34].C1(C(C2C=CC=CC=2)=[N+]=[N-])C=CC=CC=1.C(Cl)(Cl)=O>O1CCOCC1.C1(C)C=CC=CC=1>[N:18]([CH2:17][C:16]([O:15][CH:8]([C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)=[O:19])=[C:33]=[O:34]

참가 물질

7

반응물 4

HCID 6371PhosgeneHCID 612301,1'-(Diazomethylene)bis(benzene)HCID 6452034Glycine, 4-methylbenzenesulfonateHCID 66916607HCID 66916607, 화합물

생성물 1

HCID 54006150HCID 54006150, 화합물

시약·촉매·용매 2

HCID 1140Toluene용매HCID 312751,4-Dioxane용매

실험 절차

A suspension of 20 g. of glycine diphenylmethyl ester hydrochloride (prepared by reacting glycine tosylate and diphenyldiazomethane in dioxane followed by conversion to the hydrochloride salt) in 300 ml. of toluene is heated to boiling with stirring. At the boiling temperature, a strong stream of phosgene is passed through the suspension for three hours. The isocyanatoacetic acid, diphenylmethyl ester is then isolated by distillation; b.p.0.01 160°-170°.

후처리

  1. additionA suspension of 20 g

출처 및 근거

ORD 기록
ord-8aa09da9d0644d93ad5c8e4973745176
출처 데이터셋
uspto-grants-1978_06
특허 번호
US04097670

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