4-Chloro-2-toluidine → 1-(4-Chloro-o-tolyl)piperazine

반응식

F[C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[C:4]([CH3:14])[CH:3]=1.[Cl:15]C1C=CC(N)=C(C)C=1>>[Cl:15][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[C:4]([CH3:14])[CH:3]=1

참가 물질

반응물 2

HCID 72514-Chloro-2-toluidine

HCID 184230721-(4-Fluoro-2-methylphenyl)piperazine

생성물 1

HCID 1008521-(4-Chloro-o-tolyl)piperazine수율 73%

실험 절차

The title compound was prepared following the method described for the Compound 31A of Example 31 but starting from 4-chloro-2-methylaniline instead of 4-fluoro-2-methylaniline. Purification by flash chromatography (chloroform-2N ammonia in methanol 100:3 to 100:5) afforded the title compound (73%) as an oil.

후처리

customThe title compound was prepared
customPurification by flash chromatography (chloroform-2N ammonia in methanol 100:3 to 100:5)

출처 및 근거

ORD 기록: ord-9e21c63ea0f042a3b1f696420bad37f9
출처 데이터셋: uspto-grants-2002_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06365591B1

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