Water → 1-[3-(Chloromethyl)benzoyl]piperidine

HRID 840164노트

반응식

HRID 840164 반응식
[Cl:1][CH2:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6](Cl)=[O:7].[NH:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1.O>C(N(CC)CC)C>[Cl:1][CH2:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6]([N:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1)=[O:7]

참가 물질

5

반응물 3

HCID 962WaterHCID 8082PiperidineHCID 27333243-(Chloromethyl)benzoyl chloride

생성물 1

HCID 100144051-[3-(Chloromethyl)benzoyl]piperidine

시약·촉매·용매 1

HCID 8471Triethylamine용매

반응 조건

온도
5 °C

실험 절차

3-Chloromethylbenzoyl chloride (1.45 ml) was added to a solution of piperidine (1 ml) in triethylamine (2 ml) and the mixture was stirred under nitrogen at 5° C. for 45 min. Water was added, the product was extracted with dichloromethane and the extract was washed with water, dried over sodium sulphate and evaporated to give 1(3-chloromethylbenzoyl)piperidine (2.32 g) as an oil.

후처리

  1. extractionthe product was extracted with dichloromethane
  2. washthe extract was washed with water
  3. dry with materialdried over sodium sulphate
  4. customevaporated

출처 및 근거

ORD 기록
ord-9c49d763d0b545c889c9a7bf960a8df2
출처 데이터셋
uspto-grants-2002_04
특허 번호
US06365604B1

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