Formaldehyde → 2-(1-Methylpiperidin-4-yl)acetic acid

HRID 840262노트

반응식

HRID 840262 반응식
[NH:1]1[CH2:6][CH2:5][CH:4]([CH2:7][C:8]([OH:10])=[O:9])[CH2:3][CH2:2]1.[CH2:11]=O>O.[Pd]>[CH3:11][N:1]1[CH2:6][CH2:5][CH:4]([CH2:7][C:8]([OH:10])=[O:9])[CH2:3][CH2:2]1

참가 물질

5

반응물 2

HCID 712FormaldehydeHCID 15125944-Piperidineacetic acid

생성물 1

HCID 4286192-(1-Methylpiperidin-4-yl)acetic acid

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 962Water용매

실험 절차

4-Piperidinylacetic acid (4 grams) (28.0 mmoles) from Preparative Example 17A was dissolved in water (50 ml) and 37% formalin (2.72 ml) (33.6 mmoles) was added. The mixture was hydrogenated over 10% Pd-C at 55 psi at 25° C. for 68 hours. The catalyst was filtered off and washed with water. The combined filtrates were evaporated to dryness to give the title compound (MH+ 158).

후처리

  1. filtrationThe catalyst was filtered off
  2. washwashed with water
  3. customThe combined filtrates were evaporated to dryness

출처 및 근거

ORD 기록
ord-1c3b9e8a5afc43159970f1eba660e74a
출처 데이터셋
uspto-grants-2002_04
특허 번호
US06365588B1

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