3-Tert-butyl-4-methoxybenzoyl chloride → methyl 2-Hydroxy-4-[3-oxo-3-(3-tert-butyl-4-methoxyphenyl)-1-propynyl]benzoate

HRID 840443

반응식

HRID 840443 반응식
[C:1]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][C:13]=1[O:14][CH3:15])[C:8](Cl)=[O:9])([CH3:4])([CH3:3])[CH3:2].[OH:16][C:17]1[CH:26]=[C:25]([C:27]#[C:28][Si](C)(C)C)[CH:24]=[CH:23][C:18]=1[C:19]([O:21][CH3:22])=[O:20]>>[OH:16][C:17]1[CH:26]=[C:25]([C:27]#[C:28][C:8](=[O:9])[C:7]2[CH:11]=[CH:12][C:13]([O:14][CH3:15])=[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[CH:6]=2)[CH:24]=[CH:23][C:18]=1[C:19]([O:21][CH3:22])=[O:20]

참가 물질

3

반응물 2

HCID 136335553-Tert-butyl-4-methoxybenzoyl chlorideHCID 22641103Methyl 2-hydroxy-4-trimethylsilylethynylbenzoate

생성물 1

HCID 22619479methyl 2-Hydroxy-4-[3-oxo-3-(3-tert-butyl-4-methoxyphenyl)-1-propynyl]benzoate수율 81.9%

실험 절차

Following the basic procedure of Example 1(b), by reacting 4.2 g (0.02 mol) of 3-tert-butyl-4-methoxybenzoyl chloride with 5 g (0.02 mol) of methyl 2-hydroxy-4-trimethylsilylethynylbenzoate, 6 g (81%) of the expected compound were obtained, after purification by chromatography on a silica column eluted with dichloromethane, in the form of a brown oil.

출처 및 근거

ORD 기록
ord-69dbdf4868724514b72afeb9114e0815
출처 데이터셋
uspto-grants-2002_04
특허 번호
US06368608B1

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