4-Bromo-1-(bromomethyl)-2-(methylsulfonyl)benzene → 2-(4-Bromo-2-methanesulfonylbenzyl)isoindole-1,3-dione

HRID 840653노트

반응식

HRID 840653 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8]Br)=[C:4]([S:10]([CH3:13])(=[O:12])=[O:11])[CH:3]=1.[C:14]1(=[O:24])[NH:18][C:17](=[O:19])[C:16]2=[CH:20][CH:21]=[CH:22][CH:23]=[C:15]12.[K]>CN(C=O)C.O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:18]2[C:14](=[O:24])[C:15]3[C:16](=[CH:20][CH:21]=[CH:22][CH:23]=3)[C:17]2=[O:19])=[C:4]([S:10]([CH3:13])(=[O:12])=[O:11])[CH:3]=1

참가 물질

5

반응물 2

HCID 27610744-Bromo-1-(bromomethyl)-2-(methylsulfonyl)benzeneHCID 24194345Phthalimide potassium salt

생성물 1

HCID 226200152-(4-Bromo-2-methanesulfonylbenzyl)isoindole-1,3-dione수율 49.9%

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

3.0 g of 4-bromo-1-bromomethyl-2-methanesulfonylbenzene and 2.0 g of potassium phthalimide are stirred at 100° C. for 1 h in 30 ml of anhydrous DMF. The mixture is allowed to cool, diluted with 200 ml of water and the suspension is stirred at RT for 30 minutes. The product is then filtered off and 1.8 g of a colorless solid are obtained, mp 188-190° C.

후처리

  1. temperatureto cool
  2. filtrationThe product is then filtered off

출처 및 근거

ORD 기록
ord-efa94f2feff94153ab12111dba6eb922
출처 데이터셋
uspto-grants-2002_04
특허 번호
US06369069B1

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