5-Methoxy-3-(4-nitrophenyl)-1,3,4-oxadiazol-2(3H)-one → 3-(4-Aminophenyl)-5-methoxy-1,3,4-oxadiazol-2(3H)-one

HRID 840726노트

반응식

HRID 840726 반응식
[CH3:1][O:2][C:3]1[O:7][C:6](=[O:8])[N:5]([C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[CH:11][CH:10]=2)[N:4]=1.[H][H]>[Pd].CO>[CH3:1][O:2][C:3]1[O:7][C:6](=[O:8])[N:5]([C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][CH:10]=2)[N:4]=1

참가 물질

5

반응물 2

HCID 102361585-Methoxy-3-(4-nitrophenyl)-1,3,4-oxadiazol-2(3H)-oneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 99207173-(4-Aminophenyl)-5-methoxy-1,3,4-oxadiazol-2(3H)-one

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture consisting of 1.4 g of 5-methoxy-3-(4-nitrophenyl)-3H-(1,3,4)oxadiazol-2-one, 0.5 g of Pd/C and 20ml of methanol was hydrogenated under atmospheric pressure at room temperature until the calculated amount of hydrogen had been taken up. The catalyst was then filtered off, and the solution was concentrated in vacuo. The remaining semisolid residue was stirred with isopropanol and filtered off with suction.

후처리

  1. filtrationThe catalyst was then filtered off
  2. concentrationthe solution was concentrated in vacuo
  3. filtrationfiltered off with suction

출처 및 근거

ORD 기록
ord-c9fe2b85bfef4974a91af7e163da366c
출처 데이터셋
uspto-grants-2002_04
특허 번호
US06369088B2

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