Cyclohexanecarbonyl chloride → HCID 178521898, 화합물

HRID 840741노트

반응식

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:9][C:10]3[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][C:11]=3[N:12]=2)=[CH:4][CH:3]=1.[CH:18]1([C:24](Cl)=[O:25])[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1>>[CH:18]1([C:24]([NH:1][C:2]2[CH:3]=[CH:4][C:5]([C:8]3[NH:9][C:10]4[CH:16]=[CH:15][C:14]([NH:17][C:24]([CH:18]5[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]5)=[O:25])=[CH:13][C:11]=4[N:12]=3)=[CH:6][CH:7]=2)=[O:25])[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1

참가 물질

반응물 2

HCID 75938Cyclohexanecarbonyl chloride

HCID 178507432HCID 178507432, 화합물

생성물 1

HCID 178521898HCID 178521898, 화합물

실험 절차

2-(N-Cyclohexylcarbanoyl-4′-aminophenyl)-6-(cyclohexylcarbanoylamino)-benzimidazole was prepared by Method A from 2-(4-aminophenyl)-6-aminobenzimidazole (0.195 g, 0.87 mmole) and cyclohexylcarbonyl chloride (0.291 ml, 0.319 g, 2.175 mmole). The resulting solid (76.7 mg) was purified by preparative HPLC.

후처리

customThe resulting solid (76.7 mg) was purified by preparative HPLC

출처 및 근거

ORD 기록: ord-636f4961eeb44a5f9278115991c9dc3d
출처 데이터셋: uspto-grants-2002_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06369091B1

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