Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Hydroxymethylpyridine → 4-(Chloromethyl)pyridinium chloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Hydroxymethylpyridine | HCID 11472 | — |
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 4-(Chloromethyl)pyridinium chloride | HCID 74570 | — |
반응 단계
4-Hydroxymethylpyridine (20) (54.4 g, 0.50 mol) was dissolved in acetonitrile 202 ml. The solution was added dropwise to a mixture of thionyl chloride (65.3 g, 0.55 mol) and acetonitrile (109 ml) under 50° C. The mixture was stirred at the same temperature for 1 hour, then cooled to room temperature to yield a slurry (quantitative) of the objective (21).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07087764B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-dee3bbe8fbf245858780f3dd89a7ddd2 |
| 출처 메모 | uspto-grants-2006_08 |