Methanol → Methyl 2-amino-4-methylbenzoate

HRID 841170

반응식

HRID 841170 반응식
[NH2:1][C:2]1[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].S(=O)(=O)(O)O.[CH3:17]O>>[NH2:1][C:2]1[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:3]=1[C:4]([O:6][CH3:17])=[O:5]

참가 물질

4

반응물 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 753164-Methylanthranilic acid

생성물 1

HCID 11205965Methyl 2-amino-4-methylbenzoate

실험 절차

A mixture of 2-amino-4-methylbenzoic acid (15.0 g) and concentrated sulphuric acid (20 ml) was heated under reflux with methanol for 18 hours. After removal of the solvent the residue was dissolved in dichloromethane, basified with sodium carbonate solution and the organic phase was washed with water, dried (anhydrous magnesium sulphate) and the solvent evaporated to give methyl 2-amino-4-methylbenzoate, m.p. 41-43° C.

후처리

  1. temperaturewas heated
  2. customAfter removal of the solvent the residue
  3. dissolutionwas dissolved in dichloromethane
  4. washthe organic phase was washed with water
  5. dry with materialdried (anhydrous magnesium sulphate)
  6. customthe solvent evaporated

출처 및 근거

ORD 기록
ord-12f66173015c464e9a5c1abb28f9e048
출처 데이터셋
uspto-grants-2002_04
특허 번호
US06369270B1

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