참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1-(3-Fluorophenyl)-3,4-dihydroisoquinoline | HCID 14998903 | — |
| 촉매 | Manganese | HCID 23930 | — |
| 용매 | 1,2-Dichlorobenzene | HCID 7239 | — |
| 생성물 | 1-(3-Fluorophenyl)isoquinoline | HCID 11183669 | 100.2% |
반응 단계
266.41 g (1.183 mol) of 1-(3-fluorophenyl)-3,4-dihydroisoquinoline were dissolved in 1500 ml of o-dichlorobenzene and admixed with 901.2 g (10.37 mol, 8.7 eq.) of manganese. The mixture was stirred at 160-170° C. for 16 h. Subsequently, the reaction solution was filtered through Celite which was rinsed with dichloromethane/ethanol (25:1). Subsequently, the solvent was distilled off under reduced pressure. 264.74 g of a crystalline solid with 99% purity were obtained, corresponding to 99% of theory.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08846920B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_09 |
|---|
| ORD ID | ord-074b9979916f4467bfc2ab558275b767 |
|---|
| 출처 메모 | uspto-grants-2014_09 |
|---|
