Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Chloroform → (1-Methyl-7-methoxy-2,2-dimethyl-1,2,3,4-tetrahydroquinol-4-yl-methane-sulfonyl)-piperidine-4-carboxylic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Chloroform | HCID 6212 | — |
| 반응물 | Methyl isonipecotate | HCID 424914 | — |
| 반응물 | (1-Ethyl-2,2-dimethyl-1,2-dihydroquinol-4-yl-methanesulfonyl)-piperidine-4-carboxylic acid methyl ester | HCID 12138183 | — |
| 반응물 | (1-Methyl-7-methoxy-2,2-dimethyl-1,2,3,4-tetrahydroquinol-4-yl)-methane-sulfonic acid chloride | HCID 12138193 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | (1-Methyl-7-methoxy-2,2-dimethyl-1,2,3,4-tetrahydroquinol-4-yl-methane-sulfonyl)-piperidine-4-carboxylic acid methyl ester | HCID 12138194 | 69% |
반응 단계
(1-Methyl-7-methoxy-2,2-dimethyl-1,2,3,4-tetrahydroquinol-4-yl-methane-sulfonyl)-piperidine-4-carboxylic acid methyl ester (20) is prepared similarly to compound (10) from compound (19) and 4-piperidinecarboxylic acid methyl ester in dry acetonitrile. It is isolated by column chromatography on silica gel using a gradient running from chloroform to ethanol.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08846924B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-63e10f8f54a940598f5f9681467ddd15 |
| 출처 메모 | uspto-grants-2014_09 |