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Sodium Bicarbonate → N-(2-(1-(6-methylbenzo[d]oxazol-2-yl)piperidin-4-yloxy)phenyl)pyridine-2-sulfonamide

HRID 84169
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HRID 84169 반응식
Cl[C:2]1[O:3][C:4]2[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:5]=2[N:6]=1.FC(F)(F)C(O)=O.[NH:19]1[CH2:24][CH2:23][CH:22]([O:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=2[NH:32][S:33]([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][N:37]=2)(=[O:35])=[O:34])[CH2:21][CH2:20]1.C(=O)(O)[O-].[Na+]>CCO>[CH3:11][C:9]1[CH:8]=[CH:7][C:5]2[N:6]=[C:2]([N:19]3[CH2:24][CH2:23][CH:22]([O:25][C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=4[NH:32][S:33]([C:36]4[CH:41]=[CH:40][CH:39]=[CH:38][N:37]=4)(=[O:35])=[O:34])[CH2:21][CH2:20]3)[O:3][C:4]=2[CH:10]=1
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참가 물질

5

반응물 3

HCID 516892Sodium BicarbonateHCID 106786662-Chloro-6-methyl-benzooxazoleHCID 67607774N-(2-(piperidin-4-yloxy)phenyl)pyridine-2-sulfonamide trifluoroacetate

생성물 1

HCID 67609327N-(2-(1-(6-methylbenzo[d]oxazol-2-yl)piperidin-4-yloxy)phenyl)pyridine-2-sulfonamide수율 77%

시약·촉매·용매 1

HCID 702Ethanol용매

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온도
80 °C

실험 절차

Compound 21 is prepared using synthesis method 3: intermediate 2e (0.21 g, 1.25 mmol) and intermediate 6a are placed in 5 mL of EtOH in the presence of 0.3 g (3.58 mmol) of sodium bicarbonate, and the mixture is then stirred for 2 h at 80° C. After evaporation under reduced pressure the residue is taken up by water and extracted using AcOEt. After drying of the organic phases and reduction to dryness the residue obtained is triturated in a mixture of EtOH/Et2O and 0.32 g of solid is isolated by filtration (yield: 77%).

후처리

  1. customsynthesis method 3
  2. customAfter evaporation under reduced pressure the residue
  3. extractionextracted
  4. customAfter drying of the organic phases and reduction to dryness the residue
  5. customobtained
  6. customis triturated in a mixture of EtOH/Et2O

출처 및 근거

ORD 기록
ord-f760e7b2fb894a1abd9ce55ee6c9562b
출처 데이터셋
uspto-grants-2014_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08846930B2

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