Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Lithium Hydroxide → 1-benzenesulfonyl-1H-indole-5-carboxylic acid hydroxyamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Lithium Hydroxide | HCID 3939 | — |
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | Benzenesulfonyl chloride | HCID 7369 | — |
| 반응물 | Benzyl Chloride | HCID 7503 | — |
| 반응물 | PyBOP | HCID 2724699 | — |
| 반응물 | O-(Tetrahydropyran-2-yl)hydroxylamine | HCID 5142091 | — |
| 반응물 | Potassium tert-butoxide | HCID 23665647 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 1-benzenesulfonyl-1H-indole-5-carboxylic acid hydroxyamide | HCID 53464575 | — |
반응 단계
Compound 1 was synthesized via the route as shown in Scheme 1 above (reagents and conditions: a) benzyl chloride or benzenesulfonyl chloride, t-BuOK, KI, DMF; b) 1M LiOH(aq), dioxane; c) (i) NH2OTHP, PyBOP, NEt3, DMF, rt; (ii) TFA, MeOH, rt).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08846748B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-0920744fda3c4b1fb38ee5c46c52898b |
| 출처 메모 | uspto-grants-2014_09 |