Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Anhydride → 6-Chloro-8-iodocoumarin
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Anhydride | HCID 7918 | — |
| 반응물 | 5-Chloro-2-hydroxy-3-iodobenzaldehyde | HCID 3772545 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | 6-Chloro-8-iodocoumarin | HCID 22608626 | — |
반응 단계
A mixture of 3-iodo-5-chlorosalicylaldehyde (100 g, 0.354 mole), acetic anhydride (300 mL) and triethylamine (54 mL) was heated at reflux for 18 hours. Upon cooling, the desired coumarin precipitated as a dark brown crystalline material. This was filtered, washed with hexane/ethyl acetate (4:1, 200 mL), and was air dried. Yield: 60 g (55%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06372719B1 |
| 출처 데이터셋 | uspto-grants-2002_04 |
| ORD ID | ord-ab41251c244b49318e2bfc4e760e2a8c |
| 출처 메모 | uspto-grants-2002_04 |