1-(Azidomethyl)-4-methoxybenzene → Ethyl 4-(3,4-dimethoxybenzoyl)-1H-1,2,3-triazole-5-carboxylate

HRID 841963노트

반응식

HRID 841963 반응식
COC1C=CC(CN=[N+]=[N-])=CC=1.COC1C=C(C(=O)C#CC(OCC)=O)C=CC=1OC.[CH3:32][O:33][C:34]1[CH:35]=[C:36]([CH:58]=[CH:59][C:60]=1[O:61][CH3:62])[C:37]([C:39]1[N:43](CC2C=CC(OC)=CC=2)[N:42]=[N:41][C:40]=1[C:53]([O:55][CH2:56][CH3:57])=[O:54])=[O:38].COC1C=C(C=CC=1OC)C(C1N(CC2C=CC(OC)=CC=2)NNC=1C(OCC)=O)=O>C1(C)C=CC=CC=1>[CH3:32][O:33][C:34]1[CH:35]=[C:36]([CH:58]=[CH:59][C:60]=1[O:61][CH3:62])[C:37]([C:39]1[NH:43][N:42]=[N:41][C:40]=1[C:53]([O:55][CH2:56][CH3:57])=[O:54])=[O:38]

참가 물질

6

반응물 4

HCID 109317671-(Azidomethyl)-4-methoxybenzeneHCID 22222587Ethyl 4-(3,4-Dimethoxyphenyl)-4-oxo-2-butynoate2회HCID 22222617ethyl 5-(3,4-dimethoxybenzoyl)-1-(4-methoxybenzyl)-1H-1,2,3-triazole-4-carboxylateHCID 22222632ethyl 4-(3,4-dimethoxybenzoyl)-3-(4-methoxybenzyl)-1H-1,2,3-triazole-5-carboxylate

생성물 1

HCID 178470512Ethyl 4-(3,4-dimethoxybenzoyl)-1H-1,2,3-triazole-5-carboxylate

시약·촉매·용매 1

HCID 1140Toluene용매2회

반응 조건

온도
100 °C

실험 절차

In the same manner as in Intermediate 4, a solution of 4-methoxybenzyl azide (1.8 g) in toluene (10 ml) was added to a solution of ethyl 4-(3,4-dimethoxyphenyl)-4-oxo-2-butynoate (intermediate 2) (2.4 g, 9.2 mmol) in toluene (80 ml). The mixture was stirred at 100° C. for 18 hr. The reaction solution was concentrated under reduced pressure to give a mixture of ethyl 5-(3,4-dimethoxybenzoyl)-1-(4-methoxybenzyl)-1H-1,2,3-triazole-4-carboxylate and ethyl 4-(3,4-dimethoxybenzoyl)-3-(4-methoxybenzyl)-1H-1,2,3-triazole-5-carboxylate as an oil. The oil was used in the next reaction without purification.

후처리

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. customto give
  3. customThe oil was used in the next reaction without purification

출처 및 근거

ORD 기록
ord-5290e9216d9249278e644035f79eca4c
출처 데이터셋
uspto-grants-2002_04
특허 번호
US06372735B1

반응 노트

불러오는 중…